Stability analysis of a model gene network links aging, stress resistance, and negligible senescence

Valeria Kogan, Ivan Molodtsov, Leonid I. Menshikov, Robert J. Shmookler Reis & Peter Fedichev

Abstract Several animal species are considered to exhibit what is called negligible senescence, i.e. they do not show signs of functional decline or any increase of mortality with age. Recent studies in nakedmole rat and long-lived sea urchins showed that these species do not alter their gene-expression profiles with age as much as other organisms do. This is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses. We conjectured, therefore, that the lifelong transcriptional stability of an organism may be a key determinant of longevity...

Published in Scientific Repots


Dark matter
of transhumanism

Lecture at Stanford Advancing Humanity Symposium about different scenarios of victory of transhumanism and the reasons why life extension ideas haven't yet captured the attention of every person in the world.

Positive Disruption:
Peter Fedichev at TEDxSkolkovoChange

Peter Fedichev, Ph.D. is Co-founder and Chief Scientific Officer at Quantum Pharmaceuticals.


Hacking aging is possible


Gero, the data-driven biotech company, has laid the ground for the longevity industry boom by publishing a model on how to switch aging off.

Human mortality doubles every 8 years. However, it is widely known that mortality of some animals like naked mole rats, certain turtles, clams and a number of other species does not increase with age.

The proposed mathematical model explains that the difference between these two aging regimes is attributed to the stability of the gene regulatory network. Network stability is its intrinsic property and does not depend on the accumulated damage. The difference between the two aging dynamics is based on the genome size, regulatory-network connectivity and the efficacy of repair systems.

So, it's not damage accumulation that is responsible for aging, but rather the properties of the gene network itself. This means that we need to change the features of our network and make it more stable to make humans resistant to aging. And there are ways to do it, for example, by improving DNA repair efficiency and protein quality control. With this knowledge we can understand how to transform a normally aging organism into a negligibly senescent one. In other words, we can reprogram aging.

“We hope that our theory will enable switching off aging in lab animals in the nearest time”, Gero CSO Peter Fedichev commented, “this will allow us to make progress in defeating aging in humans”.

About Gero

Gero is a data-driven drug discovery company creating first in class therapeutics using proprietary molecular modeling platform. Gero develops new treatments against cancer, other age-related diseases, and aging itself and biomarkers of aging.

Link to publication in Scientific Reports - http://www.nature.com/articles/srep13589

Link to company website www.Gero.com




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